In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed.
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Links
- Benefits and risks of testosterone treatment
- Eunuchs are long-lived
- Longevity is enhanced in mice lacking growth hormone
- MOTS-c and age-dependent physical decline in mice
- Fatty liver disease, obesity, and an analog of MOTS-C
- Humanin regulates lifespan and healthspan in mice
- Humanin ameliorates diabetes in mice
- Mouse aging can be modulated via exosomes
- Exosomes and ulcer healing in older mice
- Generating induced pluripotent stem cells
- Vision loss after ocular injections
- Mesenchymal stem cells and human frailty
- Restoring vision loss in older mice
- Reversing epigenetic age in humans
Timestamps
00:00:00 Kicking Off Episode Five: Interventions on the Cutting Edge
00:02:39 Expressing Gratitude to the Sponsors
00:05:28 Testosterone Replacement Therapy
00:10:09 Human Growth Hormone
00:13:56 Peptide Supplementation and Regenerative Signaling
00:18:11 MOTS-c, Humanin, and Other Peptides
00:25:05 Exosome Therapy
00:31:56 A Primer on Stem Cells and Yamanaka Factors
00:37:59 Stem Cell Aging and Cord Blood Banking
00:41:42 The Therapeutic Potential of Stem Cells
00:43:37 Cellular Reprogramming
00:51:35 Resetting the Aging Clock
00:56:50 The Future Looks Bright
00:58:15 Next Week’s Episode: External Aging
00:58:36 Subscription and Support Options
